TissueBase©

What is TissueBase?

TissueBase© is an innovative state of the art web-based application designed to manage the collection, processing, storage and dispatch of biological tissue specimens. TissueBase© has been designed in cooperation with Australian tissue banking scientists to create a software solution that incorporates the standards and processing protocols of a modern tissue banking operation. Its modular design allows the application to be reconfigured to support multiple tissue banking scenarios ranging from simple storage management to more sophisticated banking functionality such as managing research applications, registering trials with their collection requirements and specimen dispatch.

TissueBase© has been fully developed utilizing Oracle database technologies. Oracle is the world leader in providing a secure, scalable and robust database platform for developing and deploying web-enabled applications. Oracle offers a free database and application runtime licence for small to medium sized tissue banks. Application enhancement and customization are supported by a global labour force skilled in Oracle development. TissueBase© is a 100% web-based software solution that runs in a web browser requiring no client install and offers the user a functionally rich interface for data processing and reporting.

Hyper linking is implemented throughout which allows the user to easily navigate the application and use drill down functionality to view more detailed information. Expandable hierarchical data trees act as object navigators allowing easy access to hierarchically structured data. Colour is used throughout the application for easy identification of data and is configurable by end-users.

TissueBase© can be configured to accommodate almost any inventory requirement, for example, the storage of processed and extracted tissue specimens in inventory boxes designed to hold tubes, slides, paraffin blocks and FTA Cards. Depending on specimen storage protocols, dedicated boxes can be stored in simulated freezers or rooms designed to hold specimens at any temperature. A simulated freezer can be configured to allow any combination of rows by columns and therefore store an unlimited number of shelves, racks, boxes and cells. All levels of storage can be created in one action for an entire freezer and then later reconfigured to meet specific tissue banking needs. Contents of a whole freezer can be viewed down to the box and cell level at the one time to reveal the distribution of similar specimens or help with managing empty cell fragmentation within boxes as samples are dispatched over time. During bulk processing, specimens are automatically allocated into their appropriate boxes in the inventory. A report can be generated at any time to list the locations of all specimens for any donor.

TissueBase© was initially designed to store haematological malignant tissue samples processed from tissue sources such as Bone Marrow Aspirate, Peripheral Blood and tissue biopsies. This list can be expanded to include any number of tissue sources.

TissueBase© manages the storage of processed tissue sources to specimens such as Trizols, Cell Pellets, Cryopreserved cells, Carnoys Fixed Cells etc, and is able to support any number of different specimen types. Further specimen extractions such as RNA, DNA, Viable Cells or Microarrays can also be registered, stored and made available for trials and researcher applications.

 

Donors can be registered with their identification details remaining anonymous or else identifiable. Other details include the diagnosis according to the appropriate WHO disease classification, donor consent to permit samples to be used in trials, and other clinical results. The donor's tissue collection details can be stored and recorded at different time intervals such as baseline, relapse and follow-up. A number of collection test results such as Cytogenetic Reports, PBPC Count Reports, Molecular Reports etc, can be recorded with the ability to upload corresponding documents in any format for subsequent retrieval.

Processed specimens from each collection tissue source can be registered and assigned to the inventory individually or in bulk. Specimens can then be either de-allocated or re-allocated within the inventory. A full history of specimen movement can be retraced and displayed. Manual and automatic quarantine locks can be applied to specimens to protect them from dispatch or updates. Quality control results can be recorded against specimen extractions and in the case of DNA and RNA samples, nanodrop concentration calculations and agilent bioanalyzer results (RIN) can be stored.

The trial information module has been designed to record details of trials including manager and investigator details and the institution involved in the trial. Correlative study requirements can be entered to record the details of tissue and specimen processing, storage, transportation and courier information for a trial. Tissue donors with the appropriate consent can have their specimens assigned to a registered trial.

Processed specimens from each collection tissue source can be registered and assigned to the inventory individually or in bulk. Specimens can then be either de-allocated or re-allocated within the inventory. A full history of specimen movement can be retraced and displayed. Manual and automatic quarantine locks can be applied to specimens to protect them from dispatch or updates. Quality control results can be recorded against specimen extractions and in the case of DNA and RNA samples, nanodrop concentration calculations and agilent bioanalyzer results (RIN) can be stored.

The trial information module has been designed to record details of trials including manager and investigator details and the institution involved in the trial. Correlative study requirements can be entered to record the details of tissue and specimen processing, storage, transportation and courier information for a trial. Tissue donors with the appropriate consent can have their specimens assigned to a registered trial.

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